Queridos internautas, mi nombre es Fernando y he tenido la suerte de poder dedicar mi vida profesional a aquello a lo que me apasiona desde que era pequeño, la biología. Aquí os dejo en unas líneas mi trayectoria profesional.
Gracias al apoyo de mis padres, pude estudiar la licenciatura de Ciencias Biológicas en la Universidad de Salamanca.
Después realicé mi tesis doctoral en el Centro de Investigaciones Biológicas (CIB-CSIC) sobre proteínas del ciclo celular y la influencia de la microgravedad en el desarrollo de las plantas.
Posteriormente me trasladé al INIA donde trabajé con el virus de la peste porcina africana.
Tras un corto periodo de tiempo que permanecí en la unidad de microscopia confocal del CIB, me trasladé al Centro Nacional de Microbiología del Instituto de Salud Carlos III (CNM-ISCIII) donde permanezco en la actualidad. En este centro trabajo en la Unidad de Microscopía Electrónica y Confocal, a la vez, he participado en distintas líneas de investigación, principalmente trabajando con microorganismos como Candida, Babesia divergens, Streptococcus pneumonie y Rotavirus.
Cerré esta etapa con mi traslado al Centro del Cáncer de Salamanca, donde era responsable de la Unidad de Microscopía y colaboré estrechamente con el Dr. Faustino Mollinedo investigando sobre la cascada de señalización que conduce a la muerte celular programada (apoptosis) de células tumorales, inducido por fármacos.
Más allá de la investigación, siempre me ha interesado la formación y la divulgación científica y para saciar esta necesidad, he impartido cursos de formación de microscopia con empresas privadas, en la universidad y en los programas de formación interna de los centros en los que he trabajado, además he escrito artículos de divulgación y una exposición de fotografía científica itinerante de carácter divulgativo.
Un saludo
Fernando González-Camacho
Mis artículos en el Centro Nacional de Microbiología-Instituto de Salud Carlos III
- Título: Fist report of Babesiosis divergens infection in an HIV patient in Europe
Revista: International Journal of Infectious Diseases (Febr.
2015)
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| Figura 1 |
- Título: Pleitropic Effects of Cell Wall Amidase LytA on Streptococcus pneumoniae Sensitivity to the Host Immune Response
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| Figura 7. Fagocitosis y opsonización. |
- Título: New Insights into Rotavirus Entry Machinery: Trypsin-independent ordering of rotavirus uncleaved spike.
Revista: en PLoS Pathogens 10 (5) May 2014 PDF
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| Imagen portada de la revista PlosPathogens, mayo 2014 |
- Título: Severe babesiosis in immunocompetent man, Spais, 2011
Autores: González, L.M., Rojo, S., González-Camacho, F., Luque, D., Lobo, C., Montero, E.
Revista: Emerging Infectious Diseases 20(4):724-6 (2014). PDF
Abstract
Babesiosis, a malaria-like illness, is
transmitted through Ixodes ticks by
the zoonotic parasites, Babesia spp.
In humans, these parasites are transferred from mammalian animal reservoirs,
and the rate of infection in humans is increasing. Babesiosis also potentially
threatens the blood supply because asymptomatic infections in humans are
common; such infections can be life-threatening in some recipients (1). Most
human infection is caused by B. microti,
but babesiosis caused by B. divergens,
B. duncani, and B. venatorum has been reported.
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| Figura del artículo |
- Título: The interaction between Candida krusei and murine macrophages results in multiple outcomes, including intracellular survival and escape from killing.
Autores: García Rodas, R., González-Camacho, F., Rodriguez Tudela, JL., Cuenca Estrella, M., Zaragoza, O.
Revista: Infection and immunity. 79-6: 2136-2180 (2011) PDFPortada de la revista
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| Figura del artículo. Luz transmitida (Nomarski), actina, tinción nuclear, merge. |
Abstract
Candida krusei is a fungal pathogen of interest for the scientific community for its intrinsic resistance to fluconazole. Little is known about the interaction of this yeast with host immune cells. In this work, we have characterized the outcome of the interaction between C. krusei and murine macrophages. Once C. krusei was internalized, we observed different phenomena. In a macrophage-like cell line, C. krusei survived in a significant number of macrophages and induced filamentation and macrophage explosion. Phagocytosis of C. krusei led to actin polymerization around the yeast cells at the site of entry. Fluorescent specific staining with anti-Lamp1 and LysoTracker indicated that after fungal internalization, there was a phagolysosome maturation defect, a phenomenon that was more efficient when the macrophages phagocytosed killed yeast cells. Using cell line macrophages, we also observed macrophage fusion after cell division. When we used primary resident peritoneal macrophages in addition to macrophage explosion, we also observed a strong chemotaxis of uninfected macrophages to regions where C. krusei-infected macrophages were present. We also noticed yeast transfer phenomena between infected macrophages. Primary macrophages inhibited pseudohypha elongation more efficiently than the macrophage-like cell line, suggesting that C. krusei infection was better controlled by the former macrophages. Primary macrophages induced more tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) than the macrophage-like cell line. Our results demonstrate that C. krusei can exploit the macrophages for replication, although other different outcomes are also possible, indicating that the interaction of this pathogen with phagocytic cells is very complex and regulated by multiple factors.
Mis artículos en el Centro del Cáncer de Salamanca (IBMCC-CSIC) y en el INIA
- Título: Lipid raft connection between extrinsic and intrinsic apoptotic pathways.
Autores: Gajate, C., González-Camacho, F. and Mollinedo, F.
Revista: Biochem Biophys Res Commun., 380 (4):780-4 (2009) PDF
- Título: Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in jurkat cells.
Autores: Gajate, C., González-Camacho, F. and Mollinedo, F.
Revista: PLoS ONE 4 (4): e5044 (2009) PDF
- Título: Proapoptotic role of Hsp90 by its interaction with c-Jun N-terminal kinase in lipid rafts in edelfosine-mediated antileukemic therapy.
Autores: Nieto-Miguel, T., Gajate, C., González-Camacho, F. and Mollinedo, F.
Revista: Oncogene 27, 1779-1787 (2008) PDF
- Título: Optimization and Validation of Recombinant Serological Tests for African Swine Fever Diagnosis Based on Detection of the p30 Protein Produced in Trichoplusia ni Larvae.
Autores: Pérez-Filgueira, D., González-Camacho, F., Gallardo, C., Resino-Talaván, P., Blanco, E., Gómez-Casado, E., Alonso, C. and Escribano, JM.
Revista: J Clin Microbiol.; 44(9): 3114–3121 (2006). PDF
Mis artículos en el Centro de Investigaciones Biológicas-Consejo Superior de Investigaciones Científicas
- Título: The nucleolar structure and the activity of NopA100, a nucleolin-like protein, during the cell cycle in proliferating plant cells.
Autores: González-Camacho, F. and Medina, FJ.
Revista: Histochem Cell Biol 125 (1-2): 139-153 (2006).
- Título: Clinorotation influences rDNA and NopA100 localization in nucleoli.
Revista: Adv Space Res 36/7: 1254-1262 (2005). PDF
- Título: The nucleolar structure and nucleolar proteins as indicators of cell proliferation events in plants.
- Título: Identification of specific plant nucleolar phosphoproteins in a functional proteomic analysis.
Autores: González-Camacho, F. and Medina, FJ.
Revista: Proteomics 4:407-17 (2004). PDF
- Título: Nucleolins from different model organisms have conserved sequences reflecting the conservation of key cellular functions through evolution.
Autores: González-Camacho, F. and Medina, FJ.
Revista: J Appl Biomed 2:151-161 (2004). PDF
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